Wrinkle-reducing treatments that use botulinum toxin – Botox injectables may also be used to treat chronic migraines. These treatments, known as neuromodulating drugs (such as Botox and Dysport), were approved by FDA.
Evidence suggests that the drug interrupts the pathway of pain transmission between the brain (central nervous system) and nerves that extend from the spinal cord.
When you have a migraine, your body releases substances called neurotransmitters and molecules that are associated with pain. Botulinum toxin interferes with the transmission of these substances, typically where the nerves and muscles meet. Researchers think that when the drug is injected into the muscles around the face, head and neck, it is taken up by the nerves and interferes with pain-associated neurotransmission.